The menu path of File | Printer Setup can be used to define the Printer, Paper Size and Orientation.

Drop-down listings contain options for alternative Printers (i.e. printers that are installed on the local machine) and Paper Sizes to be selected.
On a Print Layout, the page size and the printer that is currently assigned to a plot of the active layout is shown at the bottom of the paper outline. (These are the page size and printer that were defined during the Insert Layout command.)
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It is possible to re-define either (or both) of these pieces of this information by selecting File | Printer Setup and choosing an alternative while the Layout is open (active).
If a viewport exists in the layout, when such a change to the page size has been made, the following prompt will appear:

The user can select if they would like to retain the current scale, or use a modified scale, as would be appropriate to the new paper size.
Selecting Yes will scale all plot items by the maximum amount between the X and Y axis.
If the user has made an error in their selection in this window, the Undo function can be used.